SPEAKER: Bo ZHU Tenure-track Associate Professor, Ph.D. Supervisor, PI Department of Resource and Environment, SAB

TIME ：12:45-13:30 Jan 6 2021 (Wednesday)

VENUE：Room 104, Building B, School of Agriculture and Biology

ORGANIZER：Office of Discipline and Science & Technology, SAB; Young Teachers Association, SAB

TITTLE: A-to-I editing contributes to pathogenicity and stress adaptation in Xanthomonas oryzae pv. oryzicola

ABSTRACT: 

A-to-I editing of mRNA is one of the important ways of epigenetic regulation in organisms and has important biological functions. However, the mechanism and function of A-to-I editing in bacteria is still unclear. Recently, the transcriptome of Xanthomonas oryzae pv. orizicola after interacting with rice was analyzed by a self-designed program, and two non-synonymous mutations of A-to-I editing sites were found: one occurred on fliC S128P, the other on fepA T408A. Further research indicates that both A-to-I editing events contribute to pathogenesis, biofilm formation, ROS resistance, iron uptake, and chemotaxis. Thus, Xoc could resist the oxidative stress and iron starvation stress with A-to-I editing, which enhance the niche adaptation for Xoc. Besides, the result suggests that the previously identified A-to-I editing enzyme TadA is not the only mRNA adenosine deaminase in the Xoc genome. The expected results will reveal the contribution of A-to-I editing to the pathogenicity of X. oryzae pv. orizacola and its response mechanism to environmental stress, and provide new scientific insights and theoretical basis for the prevention and control of plant diseases.